货号：ABN21

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myt1 Antibody | ABN21 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 135 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human Myt1. View All» Isotype: IgG View All» Background Information: Myelin transcription factor 1 (Myt1) is a neural specific, zinc dependent, DNA binding protein containing seven C2HC-type zinc fingers organized into two separated domains that function independently and can bind to the same DNA sequence. Myt1 plays a role in the developing CNS by stimulating the differentiation of early neuronal precursor and to specify glial cell lineage for glial cell precursors. Following birth, Myt1 induces myelin sheath production around CNS axons by activating the Schwann cell PLP gene. Observed expression of Myt1 has been reported in both oligodendrocyte lineage cells, more highly in progenitors than in differentiated oligodendrocytes, and in neural progenitors. Myt1 is primarily found in the developing CNS. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. Predicted to react with human based on immunogen design. View All» Control: PC12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC12 cell lysate.Western Blot Analysis: a 1:1000 dilution of this antibody detected Myt1 on 10 µg of PC12 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in PBS containing a final concentration of 0.5% Azide, 0.01% BSA and 0.001% Thimerosal. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q01538 View All» Entrez Gene Number: NP_004526 View All» Gene Symbol:

• MYT1

• MTF1

• C20orf36

• MYTI

• MyT1

• PLPB1
  View All» Alternate Names:
  • myelin transcription factor 1

  • proteolipid protein binding protein

  • Myelin transcription factor I

  • Proteolipid protein-binding protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. SUBUNIT STRUCTURE: Interacts with STEAP3. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICTY: Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes. DOMAIN: Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.SEQUENCE SIMILARITIES: Contains 7 C2HC-type zinc fingers.SEQUENCE CAUTION: The sequence BAA74858.2 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Myt1 View All» Concentration: 0.14 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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