货号：ABN240

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Amyloid, β 1-40, aβ Antibody | ABN240 View All» Replaces: AB5737 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the P3(40) peptide of Amyloid, β 1-40. View All» Molecular Weight: ~4 kDa observed. An uncharacterized band appears at ~19 kDa in some lysates. View All» Epitope: P3(40) peptide View All» Immunogen: KLH-conjugated linear peptide corresponding to the P3(40) peptide of human Amyloid, B 1-40. View All» Background Information: Amyloid β 1-40 is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions including axonal transport, cell adhesion, and transcription, the amyloid β 1-40 peptide has been studied mostly for its role in neurotoxicity, particularly in the context of Alzheimer’s disease. Previous studies have reported that expression of amyloid β 1-40 increases in Alzheimer’s disease and correlate with the occurrence of aberrant synaptic structure and cognitive dysfunction. These detrimental effects on neural function may be related to aggregation of this peptide (formation of neurite plaques), as neurite plaques been shown to disrupt multiple neurotransmitter systems, and synaptic events such as long-term potentiation. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse, Rat, and Bovine based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Amyloid, B 1-40 in human Alzheimer's diseased brain tissue.ELISA: A representative lot detected Amyloid, B 1-40 in ELISA (Direct). View All» Control: Human Alzhiemer brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human Alzheimer brain tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Amyloid, B 1-40 on 10 µg of human Alzheimer brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P05067 View All» Entrez Gene Number: NP_001129601 View All» Gene Symbol:

• APP

• A4

• AD1
  View All» Alternate Names:
  • Amyloid beta A4 protein

  • ABPP

  • APPI

  • APP

  • Alzheimer disease amyloid protein

  • Cerebral vascular amyloid peptide

  • CVAP

  • PreA4

  • Protease nexin-II

  • PN-II

  • 1.N-APP2.Soluble APP-alpha

  • S-APP-alpha3.Soluble APP-beta

  • S-APP-beta4.C995.Beta-amyloid protein 42

  • Beta-APP426.Beta-amyloid protein 40

  • Beta-APP407.C838.P3(42)9.P3(40)10.C8011.Gamma-secretase C-terminal fragment 59

  • Amyloid intracellular domain 59

  • AICD-59

  • AID(59)

  • Gamma-CTF(59)12.Gamma-secretase C-terminal fragment 57

  • Amyloid intracellular domain 57

  • AICD-57

  • AID(57)

  • Gamma-CTF(57)13.Gamma-secretase C-terminal fragment 50

  • Amyloid intracellular domain 50

  • AICD-50

  • AID(50)

  • Gamma-CTF(50)14.C31
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)

    • ELISA
      View All» Product Name: Anti-Amyloid, β 1-40, aβ View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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