货号：ABN28

品牌：Merck Millipore

规格：EA

目录价：￥3708.00

市场价格：￥3151.80

会员价格：￥2966.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FoxP1 Antibody | ABN28 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of FOXP1. View All» Molecular Weight: Observed molecular weight: 75 kDa. FOXP1 has 4 known isoforms of 75, 73, 64 and 54 kDa. The observed non-specific band at 115 kDa is cited in a number of FOXP1 publications. View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human FOXP1. View All» Background Information: Forkhead box protein 1 (FOXP1) is a member of the Forkhead family of transcription factors, which have been characterized as transcriptional repressors and activators, and as having a DNA-binding domain distinguished by its formation of a winged-helix motif. FOXP1 is known to be an important regulator of airway morphogenesis, lung epithelial development, and early cardiac development. It is also known to have an important role in conjunction with NFκβ in the development of B-cells and the differentiation of macrophages. Splice variants give rise to four isoforms of FOXP1. The protein is known to form homodimers and heterodimers with FOXP2 and FOXP4. Studies have indicated FOXP1 as a potential inducer of oncogenesis when over expressed. The depletion and mutation of FOXP1 expression may lead to defects in embryonic cardiac, lung and esophagus epithelial development. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with bovine, and rhesus monkey based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:300 dilution of ABN28 from a previous lot detected FOXP1 in inflammatory skin disorder and normal human kidney-glomerulus tissue.Immunocytochemistry Analysis: A 1:500 dilution of ABN28 from a previous lot detected FOXP1 in NIH/3T3, RAW264.7, and HeLa cells. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected FOXP1 in 10 µg of Jurkat cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9H334 View All» Entrez Gene Number: NP_116071 View All» Gene Symbol:
  • FOXP1

  • QRF1

  • 12CC4

  • HSPC215

  • hFKH1B
    View All» Alternate Names:
    • fork head-related protein like B

    • forkhead box P1

    • glutamine-rich factor 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development (By similarity).SUBUNIT STRUCTURE: Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity).SUBCELLULAR LOCATION: Nucleus Probable. DOMAIN: The leucine-zipper is required for dimerization and transcriptional repression By similarity.INVOLVEMENT IN DISEASE: A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.Contains 1 fork-head DNA-binding domain.SEQUENCE CAUTION: The sequence AAF36135.1 differs from that shown. Reason: Frameshift at positions 531 and 545. View All» Product Name: Anti-FoxP1 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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