货号：ABN31

品牌：Merck Millipore

规格：

目录价：￥3999.00

市场价格：￥3399.15

会员价格：￥3199.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Rhes Antibody | ABN31 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of Rhes. View All» Molecular Weight: ~33 kDa observed. UniProtKB/Swiss-Prot Q96D21 (RHES_HUMAN) lists a molecular weight of 30 kDa. A molecular weight of ~50 kDa possibly due to transcriptional variation or post-translational modification may be observed in some cell lysates (Spano, D., et al. (2004). Mol Cell Biol. 24(13):5788-5796.). View All» Epitope: C-terminus. View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human Rhes. View All» Background Information: Ras family proteins are molecular switches, which are mediated by extracellular signals and regulate intracellular signaling pathways, thereby controlling a plethora of biological functions such as cell growth, gene transcription, mRNA stability and translation, cytoskeleton organization, peptide trafficking and secrection. Ras proteins are also involved in synaptic plasticity, learning, and memory in the central nervous system.As a member of the RASD subfamily of the Ras-related GTP-binding protein superfamily, Rhes is predominantly expressed in the striatal region of the brain, where it reported to influence brain development and function. It is thought that the activation and expression of the Rhes gene is mediated by thyroid hormones in the brain. In humans, a lack of such hormones is known to cause cretinism. Additionally, Rhes -/- knockout mice display marked behavioral abnormalities, a gender-dependent increase in anxiety levels, and a clear deficit in motor coordination. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, Rat. Predicted on Rhesus Macaque based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Rhes in paraffin-embeded human pancreas cells.Western Blot Analysis: A representative lot was used by an independent laboratory in HeLa cell extracts, and in mouse striatum protein extracts. View All» Control: Human pancreas tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in human pancreas tissue lysate.Western Blot Analysis: A 1:500 dilution of this antibody detected Rhes in human pancreas tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96D21 View All» Entrez Gene Number: NP_055125 View All» Gene Symbol:
  • RASD2

  • TEM2
    View All» Alternate Names:
    • GTP-binding protein Rhes

    • Ras homolog enriched in striatum

    • Tumor endothelial marker 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a Ras-related protein that is enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades. View All» UniProt Summary: FUNCTION: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.SUBUNIT STRUCTURE: Monomer Potential. Interacts with PIK3CA and UBE2I By similarity. Interacts with GNB1, GNB2 and GNB3. Interacts with HTT; interacts with mutant HTT (mHTT) with a much higher affinity than wild type HTT.SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. View All» Product Name: Anti-Rhes View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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