货号：ABN32

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PDE9A Antibody | ABN32 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~75 kDa observed. Uniprot describes 16 isoforms produced by alternative splicing, which have been observed at various molecular weights. (Kruse, L.S., et al. (2009). Brain Res. 1281: 25-34; Rentero, C., et al. (2003). Biochem Biophys Res Commun. 301(3):686-692.) View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human PDE9A. View All» Background Information: PDE9A is a ubiquitous protein belonging to the cyclic nucleotide phosphodiesterase family which regulate the signaling of cyclic nucleotides such as cGMP and cAMP. PDE9A has a higher affinity for cGMP. It contains a catalytic site that associates with cofactors and hydrolyzes cGMP thereby terminating cGMP signaling for a number of cellular processes. PDE9A has been indirectly linked to signaling pathways involved in cognitive processes. Previous studies suggested that inhibition of PDE9A enhanced long-term potentiation (a widely studied mechanism of learning and memory); PDE9A may also effect changes in the plasticity of hippocampal neurons which are also important for certain types of cognitive processes. In addition to the brain, PDE9A is also highly expressed in the spleen, prostate, colon, kidney, and heart and may be involved in a range of physiological processes in these systems, via cGMP-amplified signaling. View All» Species Reactivity:

• Human

• Mouse

• Rhesus Macaque

• Rat

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rhesus Macaque. Predicted to react with Rat and Chimpanzee based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A representative lot of this antibody detected PDE9A in human liver tissue lysate, and in mouse spleen and liver tissue lysates.Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected PDE9 in human prostate tissue, and in possible golgi type II and basket cells in the Purkinje and molecular layers of mouse cerebellum. View All» Control: Human spleen tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human spleen tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected PDE9A in 10 µg of human spleen tissue lysate. View All» Purification Method: Protein A purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O76083 View All» Entrez Gene Number: NP_002597 View All» Gene Symbol: PDE9A View All» Alternate Names: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.CATALYTIC ACTIVITY: Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.ENZYME REGULATION: Inhibited by zaprinast.SUBCELLULAR LOCATION: Isoform PDE9A1: Cell projection > ruffle membrane. Cytoplasm > perinuclear region. Golgi apparatus. Endoplasmic reticulum. Isoform PDE9A2: Cell projection > ruffle membrane. Cytoplasm > perinuclear region. Isoform PDE9A3: Cytoplasm. Endoplasmic reticulum. Isoform PDE9A17: Cytoplasm. Endoplasmic reticulum.TISSUE SPECIFICITY: Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate.DOMAIN: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.SEQUENCE SIMILARITIES: Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily. View All» Product Name: Anti-PDE9A View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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