货号：ABN325

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SAPAP3 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes isoforms SAPAP3α and SAPAP3β. View All» Molecular Weight: ~110/130 kDa observed. View All» Immunogen: KLH-conjugated linear peptide corresponding to human SAPAP3. View All» Background Information: SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist. View All» Species Reactivity:

• Mouse

• Rat

• Human
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Rat. Predicted to react with Human based on immunogen design. View All» Application Notes: Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SAPAP3 in mouse midbrain tissue. View All» Control: Rat brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain tissue lysate.Western Blot Analysis: 2 µg/mL of this antibody detected SAPAP3 in 15 µg/mL of rat brain tissue lysate. View All» Purification Method: Antigen Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O95886 View All» Gene Symbol: DLGAP1 View All» Alternate Names:
  • SAP90

  • PSD-95-associated protein 3

  • Disks large-associated protein 3

  • DLGAP3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Product Name: Anti-SAPAP3 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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