货号：ABN328

品牌：Merck Millipore

规格：100Ug

目录价：￥4497.00

市场价格：￥3822.45

会员价格：￥3597.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Rcan2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes isoforms Rcan2-S and Rcan2-L. (Porta, S., et al. (2007). Eur J Neurosci. 26(5):1213-1226.) View All» Molecular Weight: ~22/35 kDa observed. Uncharacterized bands may appear at ~73 kDa and ~135 kDa in some lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse Rcan2. View All» Background Information: Calcipressin-2 (Rcan2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin’s activity. Unlike isoform 1 of Anti-Rcan2, the expression of the second isoform is not induced by the thyroid hormone T3. Anti-Rcan2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of Rcan2 are known to exist. View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Western Blot Analysis: 2 µg/mL from a representative lot detected Rcan2 in 15 µg/mL of NIH/3T3 cell lysate.Immunohistochemistry Analysis: 1:500-2,000 dilution from a representative lot detected Rcan2 in rat hippocampus and human midbrain tissues. View All» Control: PC12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC12 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Rcan2 in 10 µg/mL of PC12 cell lysate. View All» Purification Method: Antigen Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9JHG2 View All» Gene Symbol: RCAN2 View All» Alternate Names:
  • Rcan2

  • Regulator of calcineurin 2

  • ZAKI4

  • DSCR1L1

  • Calcipressin-2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Product Name: Anti-Rcan2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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