货号：ABN35

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurexin-1-alpha Antibody | ABN35 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Neurexin-1-alpha at the extracellular laminin G-like 3 domain. View All» Molecular Weight: ~170/45 kDa observed. Although the theoretical full length of Neurexin-1-alpha is 161 kDa, the protein detected in human brain lysates may show a band around 170 kDa and additional bands around 45 kDa as a possible result of the posttranslational processing previously reported. View All» Epitope: Extracellular laminin G-like 3 domain View All» Immunogen: Bovine thyroglobulin-conjugated linear peptide corresponding to human Neurexin-1-alpha at the extracellular laminin G-like 3 domain. View All» Background Information: Neurexins are heavily glycosylated and processed neuronal transmembrane cell surface proteins likely involved in cell recognition and adhesion (see review by Missler & Sudhof, 1998). Antibody Anti-Neurexin-1-alpha (ABN35) was made against a peptide immunogen corresponding to a stretch of amino acids in the extracellular domain of human Neurexin-1-alpha (Uniprot Q9ULB1). Although the theoretical full length of Neurexin-1-alpha is 161 kDa, the protein detected in human brain lysates may show a band around 170 kDa and additional bands around 45 kDa as a possible result of the posttranslational processing previously reported. The Immunohistochemical staining using ABN35 localizes this protein to neuronal cytoplasm also consistent with previous research (Dean et al., 2003). View All» Species Reactivity:

• Human

• Rat

• Mouse

• Chimpanzee

• Rhesus Macaque

• Canine

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with Human, Rat, and Mouse. Predicted to react with Chimpanzee, Rhesus Macaque, Canine, and Bovine based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A 1:1,000 dilution from a representative lot detected Neurexin-1-alpha on 10 µg of human brain tissue lysate.Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Neurexin-1-alpha in human brain tissue. View All» Control: Human cerebellum tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human cerebellum tissue lysate.Western Blot Analysis: A 1:1,000 dilution from a representative lot detected Neurexin-1-alpha in human cerebellum tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Guinea pig polyclonal in serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9ULB1 View All» Entrez Gene Number: NP_004792 View All» Gene Symbol: NRXN1 View All» Alternate Names:
  • Neurexin-1-alpha

  • Neurexin I-alpha

  • Neurexin1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.SUBUNIT STRUCTURE: The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan and to alpha-latroxin. Interacts with SYT13 and SYTL1 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential. TISSUE SPECIFICITY: Heart and brain.PTM: N- and O-glycosylated (By similarity).SEQUENCE SIMILARITIES: Belongs to the neurexin family.Contains 3 EGF-like domains.Contains 6 laminin G-like domains.SEQUENCE CAUTION: The sequence BAA25504.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. View All» Product Name: Anti-Neurexin-1-alpha View All» Concentration: N/A mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Guinea Pig View All»
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