货号：ABN37

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Homer1 Antibody | ABN37 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Homer1 (Vesl-1S) and its splicing variant Vesl-1L. View All» Molecular Weight: ~47 kDa observed. Uniprot describes 3 isoforms produced by alternative splicing at ~40 kDa, ~25 kDa, and ~19 kDa. Uncharacterized bands may be observed in some tissue lysates. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Homer1. View All» Background Information: Also known as Vesl-1S, Homer1 is an activity-induced neuronal protein that is expressed at a low level in its resting state and is induced by neuronal activities such as long-term potentiation (LTP), seizure, and stimulations like inflammatory pain, depolarization, and dopamine. However, further research is still required to elucidate its mode of action, Homer1 was shown to play a role in the onset of synaptic remodeling and regulate the activity-induced biphasic changes of post- and pre-synaptic sites. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Horse
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with equine based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Homer1 in neurons of human brain tissue. View All» Control: Mouse brain tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody recognizes Homer1 in 10 µg of mouse brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q86YM7 View All» Entrez Gene Number: NP_004263 View All» Gene Symbol:
  • HOMER1

  • SYN47
    View All» Alternate Names:
    • Homer protein homolog 1

    • Homer1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. View All» UniProt Summary: FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.SUBUNIT STRUCTURE: Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization.SUBCELLULAR LOCATION: Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Note: Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. View All» Product Name: Anti-Homer1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Target / Localization: Postsynaptic View All» Format: Affinity Purified View All» Host: Rabbit View All»
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