货号：ABN44

品牌：Merck Millipore

规格：100Ug

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FGF10 Antibody | ABN44 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~23 kDa observed View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human FGF10. View All» Background Information: Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor family and plays an essential role in the regulation of cell differentiation, tissue repair, tumor growth, embryonic development, and cell proliferation. Mutations in FGF10 have been associated lacrimo-auriculo-dento-digital syndrome (LADDS) which is a form of ectodermal dysplasia. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Rhesus Macaque based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a representative lot detected FGF10 on 10 µg of mouse embryo tissue lysate.Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected FGF10 in mouse epithelial cells, mouse liver, human brain, and human cerebellum tissues. View All» Control: A549 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A549 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected FGF10 on 10 µg of A549 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified Rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4) and 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O15520 View All» Entrez Gene Number: NP_004456 View All» Gene Symbol: FGF10 View All» Alternate Names:
  • Fibroblast growth factor 10

  • FGF-10

  • Keratinocyte growth factor 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Ref.8SUBUNIT STRUCTURE: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Ref.7 Ref.8SUBCELLULAR LOCATION: Secreted Potential. INVOLVEMENT IN DISEASE: Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections. Ref.11DEFECTS: in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. Ref.12 Ref.13SEQUENCE SIMILARITIES: Belongs to the heparin-binding growth factors family. View All» Product Name: Anti-FGF10 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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