货号：ABN58

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho MAP1B (Thr1265) Antibody | ABN58 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes MAP1B phosphorylated at Thr1265. View All» Molecular Weight: ~300 kDa observed View All» Epitope: Phosphorylated Thr1265 View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse MAP1B phosphorylated at Thr1265. View All» Modifications: Phosphorylation View All» Background Information: Microtubule-associated protein 1B (MAP1B) is neuron-specific and is thought to play a part in controlling the neuronal cytoskeleton. MAP1B is made up of heavy and light chains and is involved in the microtubule and actin filament association. MAP1B may have an important role in axon formation by supporting microtubule dynamics and controlling cytoskeletal arrangement. MAP1B has also been associated with Netrin 1 signaling. View All» Species Reactivity:

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Rat. Predicted to react with Mouse based on immunogen design. Other homologies: Human (91% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: 1:600 dilution from a representative lot detected MAP1B in embryonic (E12) rat spinal cord tissue. (Image courtesy of Dr. Phillip R. Gordon-Weeks, King's College London.)Immunofluorescence Analysis: A representative lot was used by an independent laboratory in IF. (Trivedi, N., et al. (2005). Journal of Cell Science. 118:993-1005.) View All» Control: S1 rat brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in S1 rat brain tissue lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected MAP1B on 10 µg of S1 rat brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in PBS containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P14873 View All» Gene Symbol:
  • Map1b

  • Mtap1b

  • Mtap5
    View All» Alternate Names:
    • Microtubule-associated protein 1B

    • MAP-1B

    • MAP1(X)

    • MAP1.2

    • MAP1 light chain LC1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: The function of brain MAPS is essentially unknown. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B Binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.SUBUNIT STRUCTURE: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts (via C-terminus) with GAN (via Kelch domains). SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton Probable. DOMAIN: Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules. PTM: LC1 is coexpressed with MAP1B. It is a polypeptide generated from MAP1B by proteolytic processing. It is free to associate with both MAP1A and MAP1B. It interacts with the N-terminal region of MAP1B.Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SEQUENCE SIMLARITIES: Belongs to the MAP1 family. View All» Product Name: Anti-phospho MAP1B (Thr1265) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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