货号：ABN63

品牌：Merck Millipore

规格：

目录价：￥4502.00

市场价格：￥3826.70

会员价格：￥3601.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GPx1 Antibody | ABN63 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes GPx1 near the C-terminus. View All» Molecular Weight: ~22 kDa observed. An uncharacterized band appears at ~40 kDa in some lysates. View All» Epitope: Near C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human GPx1 near the C-terminus. View All» Background Information: Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides. It functions in the protection of cells against oxidative damage and can be found mainly in the cytosol of mammalian cells. GPx is unusual in its content of a selenocysteine residue in its active site. Animal models have demonistrated a role for GPx1 in protection against oxidative stress in neurons, cataract formation, and heart failure. View All» Species Reactivity:

• Human

• Pig

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Porcine and Chimpanzee based on 100% sequence homology. Other homologies: Rat (92% sequence homology) and Mouse (71% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GPx1 in human brain tissues. View All» Control: THP-1 cell lysate View All» Quality Assurance: Evaluated by Western Blot in THP-1 cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected GPx1 on 10 µg of THP-1 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P07203 View All» Entrez Gene Number: NP_000572 View All» Gene Symbol: GPX1 View All» Alternate Names: Cellular glutathione peroxidase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Protects the hemoglobin in erythrocytes from oxidative breakdown.CATALYTIC ACTIVITY: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O.SUBUNIT STRUCTURE: Homotetramer.SUBCELLULAR LOCATION: Cytoplasm. SEQUENCE SIMILARITIES: Belongs to the glutathione peroxidase family. View All» Product Name: Anti-GPx1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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