货号：ABN65

品牌：Merck Millipore

规格：1X100UG

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LXRbeta Antibody | ABN65 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of LXRbeta. View All» Molecular Weight: ~55 kDa observed. A molecular weight band of ~60 kDA due to SUMOlyation may be observed in some cell lysates (Lee, J.H., et al. (2009). Mol Cell. 35(6):806-817). View All» Epitope: N-terminus. View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human LXRbeta. View All» Background Information: LXRa and LXRb (NR1H3 and NR1H2, respectively) are ligand-activated nuclear receptors that mediate cholesterol homeostasis. Once activated, LXRs upregulate the transcription of genes involved in cholesterol transport such as those encoding ATP-binding cassette (ABC) transporters, including ATP-binding cassette protein A (ABCA)1 and apolipoprotein E (Apo E), in various brain diseases. ABCA1 is known to carry and deliver cholesterol through receptor-mediated endocytosis, while in Alzheimer’s brain, both ABCA1 and Apo E are shown to influence amyloid-beta transport and clearance. It is also shown that LXR ligands inhibit STAT1 binding to related gene promoters and the downstream expression of IRF1, TNFa, and IL-6. One study reports that differential SUMOlyation of LXRa and LXRb positively transrepresses STAT1 inflammatory signaling in IFN-g-stimulated rat brain astrocytes and that transient tranfection of specific individual siRNAs against LXRb and LXRa blocks LXR-induced suppression of IRF1 and TNFa expression. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Other homologies: Mouse (85% sequence homology) Rat (70% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: 1:300 dilution from a representitive lot detected LXRbeta in human cerebellum tissue. View All» Control: Human cerebellum tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human cerebellum tissue lysate.Western Blot Analysis: 1 mg/mL of this antibody detected LXRbeta in human cerebellum tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P55055 View All» Entrez Gene Number: NP_009052 View All» Gene Symbol:

• NR1H2

• LXRB

• NER

• UNR
  View All» Alternate Names:
  • Oxysterols receptor LXR-beta

  • liver X receptor beta

  • Nnclear receptor NER

  • Nuclear receptor subfamily 1 group H member 2

  • Ubiquitously-expressed nuclear receptor
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements. View All» UniProt Summary: FUNCTION: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 By similarity.SUBUNIT STRUCTURE: Forms a heterodimer with RXR.SUBCELLULAR LOCATION: Nucleus Potential. View All» Product Name: Anti-LXRbeta View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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