货号：ABN66

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cholesterol acyltransferase 1 Antibody | ABN66 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~58 kDa observed which may be the result of dimerization/aggregation of the native protein during sample preparation for SDS-PAGE. The calculated molecular weight is 65 kDa. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Cholesterol acyltransferase 1. View All» Background Information: Cholesterol acyltransferase 1 (ACAT1) is mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA and plays a significant role in ketone body metabolism. Defects in the gene encoding ACAT1 are associated with the alpha-methylacetoaceticaciduria disorder,an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. Recent studies suggests that ACAT1 may be a therapeutic target for treating certain forms of Alzeheimer's disease. View All» Species Reactivity:

• Human

• Rhesus Macaque

• Chimpanzee

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rhesus Macaque, Chimpanzee, and Rat based on 100% sequence homology. Other homologies: Mouse (93% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Cholesterol acyltransferase 1 in human adrenal gland and normal human brain tissues. View All» Control: Caco-2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in Caco-2 cell lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected Cholesterol acyltransferase 1 on 10 µg of Caco-2 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35610 View All» Entrez Gene Number: NP_003092 View All» Gene Symbol:
  • SOAT1

  • ACACT

  • ACACT1

  • ACAT

  • ACAT1

  • SOAT

  • STAT
    View All» Alternate Names:
    • Sterol O-acyltransferase 1

    • Acyl-coenzyme A:cholesterol acyltransferase 1

    • ACAT-1

    • Cholesterol acyltransferase 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: Acyl-coenzyme A:cholesterol acyltransferase (ACACT; EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988). View All» UniProt Summary: FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.CATALYTIC ACTIVITY: Acyl-CoA + cholesterol = CoA + cholesterol ester.SUBUNIT STRUCTURE: May form homo- or heterodimers.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. INDUCTION: Highly activated by the presence of cholesterol.SEQUENCE SIMILARITIES: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. View All» Product Name: Anti-Cholesterol acyltransferase 1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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