货号：ABS157

品牌：Merck Millipore

规格：

目录价：￥3155.00

市场价格：￥2681.75

会员价格：￥2524.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SKAR Antibody | ABS157 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~51 kDa observed. An uncharacterized band appears at ~90 kDa in some lysates. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human SKAR. View All» Background Information: SKAR (S6K1 Aly/REF-like substrate) is a nuclear protein that is localized at exon junction complexes (EJC) which interact with pre-mRNA molecules to ensure that correct splicing has occurred. SKAR recruits ribosomal protein S6 kinase 1 (S6K1) to EJCs and links S6K1 to the mTOR pathway. Although the function of SKAR has not been elucidated, previous studies suggest that it plays an important role in the quality control machinery that checks newly synthesized mRNA for errors and assembles the translation apparatus, thereby regulating the synthesis of new proteins and possible cell growth. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Other homologies: Mouse (93% sequence homology). View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected SKAR in HeLa cells. View All» Control: Raji cell lysate View All» Quality Assurance: Evaluated by Western Blot in Raji cell lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected SKAR on 10 µg of Raji cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9BY77 View All» Entrez Gene Number: NP_115687 View All» Gene Symbol:
  • POLDIP3

  • PDIP46
    View All» Alternate Names:
    • Polymerase delta-interacting protein 3

    • 46 kDa DNA polymerase delta interaction protein

    • p46

    • S6K1 Aly/REF-like target

    • SKAR
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. SUBUNIT STRUCTURE: Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. SUBCELULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note: Nucleocytoplasmic shuttling protein. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated at Ser-383 and Ser-385 by RPS6KB1. SEQUENCE SIMILARITIES: Contains 1 RRM (RNA recognition motif) domain.SEQUENCE CAUTION: The sequence BAB33368.2 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-SKAR View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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