货号：ABS179

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ADAP1 Antibody | ABS179 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of ADAP1. View All» Molecular Weight: ~44 kDa observed View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human ADAP1. View All» Background Information: Arf-GAP with dual PH domain-containing protein 1 (ADAP1), also known as p42(IP4), PIP3BP, or centaurin-alpha1, is a highly abundant brain protein that has been detected in the hippocampus, cerebellum, cortex, and hypothalamus. It is an actin-binding protein that has been localized to the nucleus, cytoplasm, plasma membrane, and mitochondria. ADAP1 contains a zinc finger motif and two pleckstrin homology domains. It functions as a receptor for inositol(1,3,4,5)tetrakisphosphate and phosphatidylinositol(3,4,5)trisphosphate second messengers, and also binds to and becomes phosphorylated by all isoforms of PKC. It has been linked to calcium transport in the mitochondria and RNA metabolism in the nucleus. In addition, it has been shown that ADAP1 modulates the development and differentiation of dendrites in hippocampal cells, as it is involved in the formation of dendritic filopodia and spine-like protrusions. It has also been reported that ADAP1 is upregulated in Alzheimer’s disease. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunohistochemistry Analysis: A representative lot detected ADAP1 in normal mouse cerebellum and hippocampus tissues.Western Blot Analysis: A representative lot detected ADAP1 in human brain tissue lysate. View All» Control: Mouse brain tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 1 mg/mL of this antibody detected ADAP1 in 10 µg of mouse brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O75689 View All» Entrez Gene Number: NP_006860 View All» Gene Symbol:
  • ADAP1

  • CENTA1
    View All» Alternate Names:
    • Arf-GAP with dual PH domain-containing protein 1

    • Centaurin-alpha-1

    • Cnt-a1

    • Putative MAPK-activating protein PM25
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Product Name: Anti-ADAP1 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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