R&D Systems代理MAB313 Human Tie-2 MAb (Clone 83711) (500 UG)-试剂-金山科研平台

R&D Systems代理MAB313 Human Tie-2 MAb (Clone 83711) (500 UG)

2025-06-28

货号：MAB313

品牌：R&D Systems

规格：500ug

目录价：￥5070.00

市场价格：￥4056.00

会员价格：￥4056.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Tie-2 Long Name: Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains 2 Aliases: CD202b; TEK Entrez Gene IDs: 7010 (Human); 21687 (Mouse); 30747 (Zebrafish) Background: Tie-2

View Tie-2 IHC images. Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2.

Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

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