货号：ABS187

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Spred-3 Antibody | ABS187 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~43 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human Spred-3. View All» Background Information: Spred-3 is a tyrosine kinase substrate which has a cysteine-rich domain which resembles the SPR domain at the carboxy terminus. Spred-3 associated with Ras, blocks phosphorylation of Raf and disrupts MAP kinase signaling during the differentiation of neuronal cells and myocytes. It is almost exclusively expressed in the brain. Spred-3 has been shown to be ubiquitinated in HEK293T cells when stimulated with EGF. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated by Western Blot in K562 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Spred-3 on 10 µg of K562 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q2MJR0 View All» Entrez Gene Number: NP_001035987 View All» Gene Symbol:

• Spred3

• Spred 3
  View All» Alternate Names:
  • Sprouty-related, EVH1 domain-containing protein 3

  • Spred-3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: SPRED3 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity).SUBUNIT STRUCTURE: Interacts with Ras (By similarity).SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By similarity). PTM: Phosphorylated on tyrosine (By similarity).SEQUENCE SIMILARITIES: Contains 1 KBD domain.Contains 1 SPR (sprouty) domain.Contains 1 WH1 domain. View All» Product Name: Anti-Spred-3 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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