货号：ABS223

品牌：Merck Millipore

规格：100Ug

目录价：￥3236.00

市场价格：￥2750.60

会员价格：￥2588.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RAS-Related protein Ral-A Antibody | ABS223 View All» Replaces: 07-2123 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~26 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human RAS-Related protein Ral-A. View All» Background Information: RalA is a Ras-family GTPase which has a well-documented role in tumorigenesis. RalA is activated by Ras GTPases and in turn interacts with a number of effector molecules, most notably the exocyst or Sec6/8 complex . The Sec6/8 complex is an octameric structure which plays a key role in exocytosis of secretory vesicles by forming a bridge between vesicular and plasma membranes. RalA indirectly mediates this process as it is involved in the assembly of Sec6/8; RalA interacts with components of the Sec6/8 complex including Exo84 and Sec5. RalA may promote tumorigenesis through a Ras-induced pathway involved in cell transformation, actin dynamics or exocytosis. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react in human. Predicted to react with Rat, Mouse, Equine, Porcine, and Bovine based on 100% sequence homology. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected RAS-Related protein Ral-A on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P11233 View All» Entrez Gene Number: NP_005393 View All» Gene Symbol:

• RALA

• RAL
  View All» Alternate Names: Ras-related protein Ral-A View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. ENZYME REGULATION: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).SUBUNIT STRUCTURE: Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1. Interacts with LPAR1 and LPAR2. Interacts with ADRBK1 in response to LPAR1 activation. RALA and ADRBK1 mutually inhibit each other's binding to LPAR1. SUBCELLULAR LOCATION: Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note: Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA co-localizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody. INDUCTION: Activated in an LPA-dependent manner by LPAR1 and in an LPA-independent manner by LPAR2. PTM: Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).SEQUENCE SIMILARITIES: Belongs to the small GTPase superfamily. Ras family. View All» Product Name: Anti-RAS-Related protein Ral-A View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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