货号：ABS27

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mirk protein kinase Antibody | ABS27 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~69 kDa observed. Mirk protein kinase has three isoforms: 70, 66, and 65 kDa. View All» Immunogen: Linear peptide corresponding to the C-terminal region human Mirk protein kinase. View All» Background Information: Mirk (minibrain related kinase) serine/threonine protein kinase (also known as dyrk1B) is thought to be arginine directed and available at low levels in most normal tissue, except skeletal where it is expressed in high levels, and is sharply elevated in a variety of tumor cell lines. Mirk seems to be activated as a response to the MKK3 stress stimulation and could function as an HNF1alpha transcription factor. Mirk has been associated with tumor cell survival in the Rac1 anti-apoptotic pathway. In addition, Mirk has shown to effect motility, transcription, cell cycle progression and cell survival during skeletal muscle differentiation. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse, Human, and Rat. View All» Control: NIH/3T3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in NIH/3T3 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Mirk protein kinase on 10 µg of NIH/3T3 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y463 View All» Entrez Gene Number: NP_004705 View All» Gene Symbol:
  • DYRK1B

  • MIRK
    View All» Alternate Names:
    • Dual specificity tyrosine-phosphorylation-regulated kinase 1B

    • Minibrain-related kinase

    • Mirk protein kinase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.ENZYME REGULATION: Inhibited by RANBP9.SUBUNIT STRUCTURE: Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interatcs with DCAF7. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICTY: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. PTM: Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.Contains 1 protein kinase domain.SEQUENCE CAUTION: The sequence AAC28914.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-Mirk protein kinase View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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