货号：ABS380

品牌：Merck Millipore

规格：

目录价：￥3393.00

市场价格：￥2884.05

会员价格：￥2714.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TPMT View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~28 kDa observed View All» Immunogen: GST-tagged recombinant protein corresponding to human TPMT. View All» Background Information: Thiopurine S-methyltransferase (TPMT) is a member of the methyltransferase superfamily. It is involved in the normal metabolic inactivation of thiopurine drugs such as azathioprine, 6-mercaptopurine and 6-thioguanine. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Defects in the TPMT gene leads to decreased methylation and decreased inactivation of 6MP leading to enhanced bone marrow toxicity which may cause myelosuppression, anemia, bleeding tendency, leukopenia, and infection. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected TPMT in human lung cancer tissue. View All» Control: Human kidney tissue lysate View All» Quality Assurance: Evaluated by Western Blotting in human kidney tissue lysate.Western Blotting Analysis: A 1:500 dilution of this antibody detected TPMT in 30 µg of human kidney tissue lysate. View All» Purification Method: Antigen Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.1% sodium azide and 50% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P51580 View All» Gene Symbol: TPMT View All» Alternate Names:

• Thiopurine methyltransferase

• thiopurine S methyltransferase

• TPMT
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry
    View All» Product Name: Anti-TPMT View All» Concentration: 0.15 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 150 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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