货号：ABS52

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-SMAD1 (Ser206) Antibody | ABS52 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes SMAD1 phosphorylated at Ser206. View All» Molecular Weight: ~55 kDa observed. Uncharacterized bands may appear at ~35 and ~260 kDa in some lysates. View All» Epitope: Phosphorylated Ser206 View All» Immunogen: KLH-conjugated linear peptide corresponding to human SMAD1 phosphorylated at Ser206. View All» Background Information: Smad proteins are regulators of transcription which transduce signals from TGFβ Receptors. Smad proteins homotrimerize, and when activated, two distinct homotrimers assemble into a heterosextamer. Smad proteins fall into three classes. The receptor-regulated Smad proteins, Smad 1, 2, 3, 5, and 9 couple to specific receptors and are phosphorylated by those receptors. Phosphorylated receptor-regulated Smad proteins then bind to a co-Smad, such as Smad4/DPC4, and the complex moves to the nucleus where it associates with FAST-1 to stimulate target gene transcription. A third class of Smad proteins is the inhibitory group of Smad 6, 7, 8. Smad proteins have Mad-homology domains 1 and 2 (MH1 and MH2). MH1 domains are involved in DNA binding, while MH2 domains function in homotrimerization, receptor interaction and phosphorylation. The phosphorylation of Smad proteins is the regulatory signal in their activation, and can be monitored by the use of phosphorylation state-specific antibodies. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rat, Bovine, and Porcine based on 100% sequence homology. Other homologies: Mouse (93% sequence homology). View All» Control: Untreated and BMP2 treated HEK293 cell lysates View All» Quality Assurance: Evaluated by Western Blot in untreated and BMP2 treated HEK293 cell lysates.Western Blot Analysis: 0.2 µg/mL of this antibody detected SMAD2 in 10 µg of untreated and BMP2 treated HEK293 cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15797 View All» Entrez Gene Number: NP_005891 View All» Gene Symbol:

• BSP-1

• BSP1

• CMT2D

• GARS

• HMN5
  View All» Alternate Names:
  • MAD, mothers against decapentaplegic homolog 1

  • MAD, mothers against decapentaplegic homolog 1 (Drosophila)

  • Mad-related protein 1

  • Mothers against DPP homolog 1

  • SMAD 1

  • SMAD family member 1

  • SMAD, mothers against DPP homolog 1

  • SMAD, mothers against DPP homolog 1 (Drosophila)

  • Sma- and Mad-related protein 1

  • TGF-beta signaling protein 1

  • transforming growth factor-beta-signaling protein 1

  • transforming growth factor-beta signaling protein 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-phospho-SMAD1 (Ser206) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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