金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PRL-3/PTP4A3 Long Name: Phosphatase of Regenerating Liver 3 Aliases: PTP4A3 Entrez Gene IDs: 11156 (Human); 19245 (Mouse) Background: PRLs PRL (phosphatase of regenerating liver), also known as PTP4A, dephosphorylates tyrosine residues on proteins. Three PRL variants, PRL-1 (PTP4A1), PRL-2 (PTP4A2), and PRL-3 (PTP4A3) have been identified. Prenylation at the C-terminal end targets PRL family members to membrane compartments in the cell, especially to early endosomes and the plasma membrane. PRL levels may correlate with cell migration rates and tumor invasiveness, and PRL overexpression is known to cause an increase in the metastatic capability of cancer cell lines.