货号：ABS54

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AS160 Antibody | ABS54 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes AS160 at the C-terminus. View All» Molecular Weight: ~ 160 kDa View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of mouse AS160. View All» Background Information: AS160 (Akt Substrate of 160 kDa, Akt1S1), Rab GAP (GTPase activating protein), is phosphorylated on multiple sites by Akt in response to insulin in adipocytes and contraction in muscles. AS160 is the long sought after link between the upstream insulin signaling through insulin/PI3K/Akt and GLUT4 vessicle translocation to the cell membrane. It has 6 Akt phosphorylation consensus sequences that are believed to become phosphorylated upon insulin stimulation. This phosphorylation is required for translocation of GLUT4-containing vesicles to the cell membrane1. A mutation of two or more of these phosphorylation sites results in a dramatic decrease in AS160 activity and insulin-stimulated GLUT4 redistribution at the cell membrane2. AS160 has also shown to be important for GLUT4 expcytosis2. View All» Species Reactivity:

• Mouse

• Human

• Canine

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react on canine and rat based on 100% sequence homology. Chimpanzee, equine, and ox (90% sequence homology). View All» Application Notes: Western Blot (SNAP ID) Analysis: 1 µg/mL from a previous lot detected AS160 on 10 µg of HEPG2 cell lysate.Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated AS160 from HEPG2 lysate. View All» Control: HEPG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEPG2 cell lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected AS160 on 10 µg of HEPG2 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8BYJ6 View All» Entrez Gene Number: NP_001074747 View All» Gene Symbol: AS160 View All» Alternate Names:
  • Acrg embryonic lethality minimal region ortholog

  • Akt substrate of 160 kDa

  • TBC (Tre-2, BUB2, CDC16) domain-containing protein

  • TBC1 domain family, member
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake (By similarity).SUBCELLULAR LOCATION: Cytoplasm. Note: Cytoplasmic perinuclear (by similarity). TISSUE SPECIFICTY: Widely expressed, including in pancreatic beta cells. PTM: Phosphorylated by AKT1; insulin-induced.Insulin-stimulated phosphorylation is required for GLUT4 translocation. Has no effect on GLUT4 internalization.SEQUENCE SIMILARITIES: Contains 2 PID domains.Contains 1 Rab-GAP TBC domain. View All» Product Name: Anti-AS160 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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