货号：ABS55

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-InsP3R Antibody, Type 1 | ABS55 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes InsP3R at the cytoplasmic domain. View All» Molecular Weight: ~300 kDa observed. UniProtKB/Swiss-Prot P29994 (ITPR1_RAT) entry describes 8 isoforms produced by alternative splicing: Isoform 1 at 313.264 kDa, Isoform 2 at 311.498 kDa, Isoform 3 at 313.136 kDa, Isoform 4 at 311.370 kDa, Isoform 5 at 311.210 kDa, Isoform 6 at 309.444 kDa, Isoform 7 at 308.674 kDa, and Isoform 8 at 306.909 kDa. View All» Epitope: Cytoplasmic domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of rat InsP3R. View All» Background Information: The inositol (1,4,5)-trisphosphate receptor (InsP3R) regulates calcium release from storage within cells and plays an important role in neuronal function. InsP3R has been linked to Huntington’s disease. InsP3R has also been linked to the association between cAMP and Ca2+ signaling in regions of the brain, including the neostriatum. View All» Species Reactivity:

• Rat

• Human

• Mouse

• Pig

• Primate

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Predicted to react with Mouse, Porcine, Primate, and Rhesus Macaque based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:1500 dilution from a previous lot detected InsP3R in purkinje cells at the junction of the granular and molecular layers of normal rat cerebellum tissue.Immunoprecipitation Analysis: 10 µg of Anti-InsP3R, Type 1 immunoprecipitated InsP3R, Type 1 from rat brain microsomal prep RIPA lysate. View All» Control: Rat brain microsomal tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain microsomal tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected InsP3R on 10 µg of rat brain microsomal tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P29994 View All» Entrez Gene Number: NP_001007236 View All» Gene Symbol:
  • ITPR1

  • IP3R1

  • Insp3r1

  • InsP3R1

  • IP3R

  • INSP3R1

  • SCA15
    View All» Alternate Names:
    • inositol 1,4,5-triphosphate receptor, type 1

    • spinocerebellar ataxia 16

    • inositol 1,4,5-trisphosphate receptor type 1

    • Type 1 inositol 1,4,5-trisphosphate receptor

    • Type 1 InsP3 receptor

    • IP3 receptor

    • spinocerebellar ataxia 15

    • IP3 receptor isoform 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: receptor for inositol 1,4,5-triphosphate; mediates a IP3-dependent calcium influx [RGD]. View All» UniProt Summary: FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.SUBUNIT STRUCTURE: Homotetramer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Interacts with CABP1. Interacts with AHCYL1 and MRVI1 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICTY: Isoform 3 is found in the brain while isoform 7 is found in the fetal brain and peripheral tissues.DOMAIN: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.PTM: Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.Phosphorylated on tyrosine residues (By similarity).MISCELLANEOUS: Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.SEQUENCE SIMILARITIES: Belongs to the InsP3 receptor family.Contains 5 MIR domains. View All» Product Name: Anti-InsP3R, Type 1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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