货号：ABS59

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SMURF2 Antibody | ABS59 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes SMURF2. View All» Molecular Weight: ~ 80 kDa View All» Epitope: WW 1 domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the WW 1 domain of human SMURF2. View All» Background Information: SMURF2 (Smad ubiquitin regulatory factor 2) is a SMAD specific E3 ubiquitin protein ligase. Both SMURF2 and Smad ubiquitin regulatory factor 1 (SMURF1) play an important role in TFG-β signaling and are known to suppress transforming growth factor-beta (TGF-beta) family signaling. Mutations in SMURF2 have been associated with tumor formation. SMURF2 is known to interact with SMAD1, SMAD2 and SMAD7 to promote ubiquitination and proteasome-dependent degradation of these proteins. SMURF2 interacts with all members of the Smad family except Smad4. This protein is expressed in a variety of tissues and cell lines. View All» Species Reactivity:

• Human

• Mouse

• Pig

• Bovine

• Chicken

• Chimpanzee

• Xenopus
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with rat, mouse, pig, cow, chicken, chimpanzee, and Xenopus based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:400 dilution from a representative lot detected SMURF2 in ductal carcinoma in situ and infiltrating ductal carcinoma tissue. View All» Control: MCF-7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in MCF-7 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected SMURF2 on 10 µg of MCF-7 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9HAU4 View All» Entrez Gene Number: NP_073576 View All» Gene Symbol:
  • SMURF2

  • hSMURF2
    View All» Alternate Names:
    • Smad ubiquitin regulatory factor 2

    • SMAD specific E3 ubiquitin protein ligase 2

    • SMAD-specific E3 ubiquitin-protein ligase 2

    • E3 ubiquitin ligase SMURF2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.SIZE: 748 amino acids; 86196 Da SUBUNIT: Interacts with SMAD1, SMAD2, SMAD3, SMAD6 and SMAD7 but not SMAD4.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic in the presence of SMAD7.TISSUE SPECIFICITY: Widely expressed.DOMAIN: The second and third WW domains are responsible for interaction with R-SMAD (SMAD1, SMAD2 and SMAD3).SIMILARITY: Contains 1 C2 domain. & Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. & Contains 3 WW domains. View All» Product Name: Anti-SMURF2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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