货号：ABS64

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Coactosin-like protein Antibody | ABS64 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Coactosin-like protein. View All» Molecular Weight: ~16 kDa View All» Immunogen: Recombinant protein corresponding to human Coactosin-like protein. View All» Background Information: Coactosin-like protein (CLP or COTL1) is a human F-actin binding protein belonging to the actin-binding proteins ADF family, more specifically to the Coactosin subfamily. It acts to bind F-actin in a calcium-independent manner. Coactosin-like protein is also known for its direct, calcium-independent, interaction with 5-lipoxygenase, serving to up-regulate and modulate its activity. It also plays a critical role as an up-regulator leukotrine A4 synthesis, a role which has created interest in Coactosin-like protein for potential as a target antigen in pancreatic cancer. Coactosin-like protein expression is wide with highest levels observed within lung, kidney, placenta, and peripheral blood leukocytes, while lower levels have been observed in liver, pancreas and brain tissues. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Coactosin-like protein on 10 µg of A431 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q14019 View All» Entrez Gene Number: NP_066972 View All» Gene Symbol:
  • COTL1

  • CLP
    View All» Alternate Names:
    • coactosin-like 1 (Dictyostelium)

    • coactosin-like 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. SUBUNIT STRUCTURE: Interacts with 5-lipoxygenase (5LO) in a calcium-independent manner. SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton (By similarity). TISSUE SPECIFICTY: Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. SEQUENCE SIMLARITIES: Belongs to the actin-binding proteins ADF family. Coactosin subfamily.Contains 1 ADF-H domain. View All» Product Name: Anti-Coactosin-like protein View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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