货号：ABS73

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-WAS protein family homolog 1 (N-terminus) Antibody | ABS73 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes WAS protein family homolog 1 at the N-terminus. View All» Molecular Weight: ~ 60 kDa observed. The calculated molecular weight is 50 kDa. View All» Epitope: N-terminus View All» Immunogen: Recombinant protein corresponding to human WAS protein family homolog 1 at the N-terminus. View All» Isotype: IgG View All» Background Information: Wiskott-Aldrich Syndrome Protein and SCAR Homolog (WASH) is a novel protein belonging to the WASP family, a group of nucleation promoting factors (NFPs) that activate a critical component in endocytosis, Arp 2/3. WASH contains three specific domains: a C-terminal VCA domain, a proline-rich domain, and an N terminal region containing two WASH homolog regions, WHD1 and WHD2. Although WASH has yet to be completely characterized, it is known to function as an NPF at the endosomal surface, where it is involved in the recruitment and subsequent activation of Arp2/3 in order to initiate actin polymerization. Therefore, WASH has a crucial role in endosomal sorting as a mediator of tubule fission resulting from Arp2/3 activation. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected WAS protein family homolog 1 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: A8K0Z3 View All» Entrez Gene Number: NP_878908 View All» Gene Symbol:

• WASH1

• FAM39E
  View All» Alternate Names:
  • WAS protein family homolog 1

  • family with sequence similarity 39, member E

  • CXYorf1-like protein on chromosome 2

  • Protein FAM39E
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. SUBUNIT STRUCTURE: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct. Interacts with alpha-tubulin. SUBCELLULAR LOCATION: Early endosome membrane. Recycling endosome membrane By similarity. Note: Localization to the endodome membrane is mediated via its interaction with FAM21. MISCELLANEOUS: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (Ref.4). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene.SEQUENCE SIMILARITIES: Belongs to the WASH1 family.Contains 1 WH2 domain. View All» Product Name: Anti-WAS protein family homolog 1 (N-terminus) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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