货号：ABS95

品牌：Merck Millipore

规格：

目录价：￥3236.00

市场价格：￥2750.60

会员价格：￥2588.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NDK A Antibody | ABS95 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~17 kDa observed. Uniprot describes 3 isoforms produced by alternative splicing; two of which have molecular weights of 17 and 19 kDa respectively. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human NDK A. View All» Background Information: NME1/NDK A is a metastasis-suppressor protein that has been found to be down-regulated in human lung cancer cells. Polymorphisms in NDK A have shown a significant association with propensity and severity of lung cancer, breast cancer and other forms of human cancer. NDK A is known as a tumor metastasis suppressor that works on a wide range of tumors. Recently, NDK A has also been found to regulate subcellular trafficking of annexin IV and EF-1Bα. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Chimpanzee based on 100% sequence homology. View All» Control: MCF7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in MCF7 cell lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected NDK A on 10 µg of MCF7 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P15531 View All» Entrez Gene Number: NP_000260 View All» Gene Symbol:
  • NME1

  • NDPKA

  • NM23
    View All» Alternate Names:
    • Nucleoside diphosphate kinase A

    • NDK A

    • NDP kinase A

    • Granzyme A-activated Dnase

    • GAAD

    • Metastasis inhibition factor nm23

    • Tumor metastatic process-associated protein

    • nm23-H1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.COFACTOR: Magnesium.ENZYME REGULATION: Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits exonuclease activity.SUBUNIT STRUCTURE: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and PRUNE. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. TISSUE SPECIFICTY: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. MISCELLANEOUS: The role of this protein in tumor development and progression is uncertain. This protein is found in reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with aggressive tumor features in neuroblastoma. May have distinct if not opposite roles in different tumors.SEQUENCE SIMILARITIES: Belongs to the NDK family.SEQUENCE CAUTION: The sequence CAA35621.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. View All» Product Name: Anti-NDK A View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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