货号：ABT106

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tric-A Antibody | ABT106 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~27 kDa observed. The expected MW is ~33 kDa, however in western blot an ~27 kDa band can be observed in multiple tissue lysates, including Human heart and Human Fetal skeletal muscle (Zhao, X., et al. (2010). J Biol Chem. 285:37370-37376). View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse Tric-A. View All» Background Information: TRIC-A (Trimeric intracellular cation channel type A) is one of two TRIC (trimeric intracellular cation) Ca2+ counter-ion channels located on the sarcoplasmic/endoplasmic reticulum membrane. TRIC-A contains three trans-membrane peptides and forms homo-trimers that are bullet-shaped. TRIC-A is a cation-selective channel that seems to be controlled by the trans-membrane voltage. TRIC-A stabilizes Ca2+ levels and loss of TRIC-A could lead to a Ca2+ overload and cause cardiac muscle failure. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse based on immunogen design. View All» Control: Human heart tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human heart tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Tric-A in 10 µg of human heart tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q3TMP8 View All» Entrez Gene Number: NP_653117 View All» Gene Symbol: Tmem38a View All» Alternate Names:
  • Trimeric intracellular cation channel type A

  • TRIC-A

  • TRICA

  • 27 kDa sarcoplasmic reticulum protein

  • Mitsugumin-33A

  • SPR-27

  • Transmembrane protein 38A
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.SUBUNIT STRUCTURE: Homotrimer (by similarity).SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane (by similarity). TISSUE SPECIFICITY: Expressed at high levels in heart and striated muscle. Also detected in brain, lung and kidney.DOMAIN: The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.DISRUPTION PHENOTYPE: Mice are viable. Mice lacking Tmem38a and Tmem38b show a weak heartbeat at E9.5 followed by loss of cardiomyocyte viability and embryonic lethality around E10.5.SEQUENCE SIMILARITIES: Belongs to the TMEM38 family. View All» Product Name: Anti-Tric-A View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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