货号：ABT115

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FucT-III Antibody | ABT115 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FucT-III at the lumenal region. View All» Molecular Weight: ~50 kDa observed. The calculated molecular weight of this protein is 42 kDa, but can be observed at ~50 kDa due to high glycosylation. (Christensen, L, et al. (2000). Glycobiology. 10(9):931-939.) View All» Epitope: Lumenal region View All» Immunogen: KLH-conjugated linear peptide corresponding to the lumenal region of human FucT-III. View All» Background Information: Alpha-(1,3)-fucosyltransferase 3 (FucT-III; Galactoside 3(4)-L-fucosyltransferase) is highly expressed in the small intestine, colon, stomach, and kidney. It is a member of the glycosyltransferase family of proteins which are involved in a glycosylation pathway that attaches fucose to Lewis epitopes of target molecules. This type of post-translational modification allows modified (fucosylated) molecules to recognize specific target substrates. Fucosyltransferases may therefore play an important role in communication at the cell surface. FucT-III may play a role in blood group determination as it is involved in the expression of antigens such as Lewis B, sialy Lewis X, Vim-2, and Lewis A. View All» Species Reactivity:

• Human

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Chimpanzee based on 100% sequence homology. No homology to Rat and Mouse was found. View All» Application Notes: Western Blot Analysis: 1 µg/mL from a representative lot detected FucT-III on 10 µg of transfected lysate and did not detect the non transfected lysate. View All» Control: Human Liver Tissue Lysate View All» Quality Assurance: Evaluated by Western Blot in human liver tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected FucT-III on 10 µg of human liver tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P21217 View All» Entrez Gene Number: Np_000140 View All» Gene Symbol:
  • Fut3

  • Ft3B

  • Le
    View All» Alternate Names:
    • Galactoside 3(4)-L-Fucosyltransferase

    • Blood Group Lewis Alpha-4-Fucosyltransferase

    • Lewis Ft

    • Fucosyltransferase 3

    • Fucosyltransferase Iii

    • Fuct-Iii

    • Alpha-(1,3)-Fucosyltransferase 3
      View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le+) individuals have an active enzyme while Lewis-negative (Le-) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.CATALYTIC ACTIVITY: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.PATHWAY: Protein modification; protein glycosylation.SUBCELLULAR LOCATION: Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein. Note: Membrane-bound form in trans cisternae of Golgi.TISSUE SPECIFICITY: Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.SEQUENCE SIMLARITIES: Belongs to the glycosyltransferase 10 family. View All» Product Name: Anti-FucT-III View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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