金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PLC-gamma 1 Long Name: Phospholipase C gamma 1 Aliases: PLCG1; PPLCA Entrez Gene IDs: 5335 (Human); 18803 (Mouse); 25738 (Rat) Background: PLC gamma-1 PLC gamma-1 is an intracellular protein that contains two SH2, one SH3, one plekstrin homology (PH), and two catalytic domains. Activated PLC gamma-1 catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to produce the second messengers inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes the release of calcium while DAG activates protein kinase C. PLC gamma-1 is activated by receptor tyrosine kinases in response to growth factors and hormones, and plays an important role in regulating cell proliferation and differentiation.