货号：ABT116

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FucT-VI Antibody | ABT116 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FucT-VI at the lumenal region. View All» Molecular Weight: ~47 kDa observed. An uncharacterized band appears at ~17 kDa in some lysates. This protein is the mature endoglycosidase H resistant form. (Borsig, L.., et al. (1999). Glycobiology. 9(11):1273–1280.) View All» Epitope: Lumenal region View All» Immunogen: KLH-conjugated linear peptide corresponding to the lumenal region of human FucT-VI. View All» Background Information: Alpha-(1,3)-fucosyltransferase 6 (FucT-VI) is a member of the glycosyltransferase family of proteins which are involved in a glycosylation pathway that attaches fucose to Lewis epitopes of target molecules. This type of post-translational modification allows modified (fucosylated) molecules to recognize specific target substrates. Fucosyltransferases may therefore play an important role in communication at the cell surface, and may be involved in selectin-mediated cell recognition and adhesion processes. FucT-VI is expressed in colon, liver, kidney, small intestine, uterus, and bladder. View All» Species Reactivity:

• Human

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Chimpanzee based on 100% sequence homology. No homology to Rat and Mouse was found. View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a representative lot detected FucT-VI on 10 µg of transfected lysate and did not detect the non transfected lysate. View All» Control: Human Kidney Tissue Lysate View All» Quality Assurance: Evaluated by Western Blot in human kidney tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected FucT-VI on 10 µg of human kidney tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P51993 View All» Entrez Gene Number: Np_000141 View All» Gene Symbol:
  • Fut6

  • Fct3A
    View All» Alternate Names:
    • Alpha-(1,3)-Fucosyltransferase

    • Fucosyltransferase 6

    • Fucosyltransferase Vi

    • Fuc-Tvi

    • Fuct-Vi

    • Galactoside 3-L-Fucosyltransferase
      View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.CATALYTIC ACTIVITY: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.PATHWAY: Protein modification; protein glycosylation.SUBCELLULAR LOCATION: Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein. Note: Membrane-bound form in trans cisternae of Golgi.TISSUE SPECIFICITY: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.POLYMORPHISM: Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIM:613852].SEQUENCE SIMILARITIES: Belongs to the glycosyltransferase 10 family. View All» Product Name: Anti-FucT-VI View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-159642.htm
      © Merck Millipore代理ABT116 Anti-FucT-VI，产品报价联系微信jinshanbio