货号：ABT12

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PMP70 Antibody | ABT12 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes PMP70. View All» Molecular Weight: ~ 70 kDa View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse PMP70 at the C-terminus. View All» Background Information: The 70-kDa peroxisomal membrane protein (PMP70) is one of the major components of peroxisomal membranes. Peroxisomes are single membrane organelles, involved in many important biochemical pathways, and are found in almost all eukaryotic cells. PMP70 is an ATP-binding cassette transporter, identified for the first time in intracellular membranes of eukaryotic cells. PMP70 is a classical marker of the peroxisomal membrane and may be involved in metabolic transport of long-chain acyl-CoA across peroxisomal membranes. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunocytochemistry Analysis: 1:100 dilution from a previous lot detected PMP70 in NIH/3T3, A431, and HeLa cells. View All» Control: Mouse liver lysate View All» Quality Assurance: Evaluated by Western Blot in mouse liver lysate.Western Blot Analysis: 0.1 µg/ml of the antibody detects PMP70 on 10 µg of mouse liver lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P55096 View All» Entrez Gene Number: NP_033017.2 View All» Gene Symbol:
  • Abcd3

  • Abc43

  • Pmp70

  • Pxmp1
    View All» Alternate Names:
    • PMP68

    • 70 kDa peroxisomal membrane protein

    • ATP-binding cassette, sub-family D, member 3

    • PXMP1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. SUBUNIT STRUCTURE: Can form heterodimers with ABCD1/ALD and ABCD2/ALDR. Dimerization is necessary to form an active transporter. Interacts with PEX19. SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein. INVOLVEMENT IN DISEASE: Defects in ABCD3 may be the cause of Zellweger syndrome type 2 (ZWS2) [MIM:170995]. ZWS2 is an autosomal recessive disorder due to defective import mechanisms for peroxisomal matrix enzymes. The clinical phenotype includes characteristic facies, progressive neurological dysfunction, liver disease and death in infancy. SEQUENCE SIMILARITIES: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. [View classification]Contains 1 ABC transmembrane type-1 domain.Contains 1 ABC transporter domain. View All» Product Name: Anti-PMP70 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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