货号：ABT13

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sarcolipin Antibody | ABT13 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~6 kDa observed. An uncharacterized band may be observed at ~13 kDa in some tissue lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human Sarcolipin. View All» Background Information: Sarcolipin (SLN) is a multidomain protein containing lumenal, cytoplasmic, and transmembrane domains. It is found in the membrane of the sarcoplasmic/endoplasmic reticulum of cardiac cells, and is involved in maintaining calcium homestasis underlying muscle contractility in the heart. Sarcoplipin achieves these effects through its regulation of the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a), a calcium transport protein that actively pumps calcium from the cytoplasm into the sarcoplasmic reticulum, resulting in relaxation of the heart muscles. Sarcolipin may also interact with phospholamban, and may contribute to heart failure. View All» Species Reactivity: Rabbit View All» Species Reactivity Note: Demonstrated to react with rabbit. Predicted to react with human based on immunogen design. Predicted to react with mouse and rat based on 100% sequence homology. View All» Control: Rabbit quadraceps tissue View All» Quality Assurance: Evaluated by Western Blot in rabbit quadraceps tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Sacolipin in rabbit quadraceps tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00631 View All» Entrez Gene Number: NP_003054 View All» Gene Symbol: SLN View All» Alternate Names: Sarcopolin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. View All» UniProt Summary: SUBUNIT STRUCTURE: Associated with calcium ATPase SERCA1.SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Single-pass membrane protein. SEQUENCE SIMILARITIES: Belongs to the sarcolipin family. View All» Product Name: Anti-Sarcolipin View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»