货号:ABT133
品牌:Merck Millipore
规格:
目录价:¥4146.00
市场价格:¥3524.10
会员价格:¥3316.80
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Description:
Anti-Lamellipodin Antibody | ABT133
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Promotional Text:
Special Shipping Offer on Antibodies100% Performance Guaranteed
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Specificity:
This antibody recognizes the pleckstrin homology domain of Lamellipodin
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Molecular Weight:
~135 kDa observed. An uncharacterized band may appear at ~12 kDa in some lysates. Uniprot describes 9 isoforms produced by alternative splicing, one at ~135 kDa and the other eight at approximatly ~70 kDa.
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Epitope:
Pleckstrin homology domain
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Immunogen:
GST-tagged recombinant protein corresponding to the pleckstrin homology domain of human Lamellipodin.
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Background Information:
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1), also commonly known as Lamellipodin, is a member of the MRL family and plays an important role in interacting with Ena/VASP proteins at the tips of filopodia and protruding lamellipodia. There are nine isoforms for Lamellipodin (RMO1, RMO1a, RMO1b, RMO1c, RMO1ab, RMO1ac, RMO1bc, RMO1abc and RMO1-RAPH1). RMO1-RAPH1 is ubiquitously expressed in a wide variety of tissues, with highest amounts in brain, heart, ovary and developing embryo.
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Species Reactivity:
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Human
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Mouse
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Rat
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Species Reactivity Note:
Demonstrated to react with Human, Mouse, and Rat.
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Application Notes:
Immunocychemistry Analysis: A 1:1,000 dilution from a representative lot detected Lamellipodin in HeLa cells.
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Control:
Rat E16 brain tissue lysate
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Quality Assurance:
Evaluated by Western Blot in rat E16 brain tissue lysate.Western Blot Analysis: 0.2 µg/mL of this antibody detected Lamellipodin in 10 µg of rat E16 brain tissue lysate.
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Purification Method:
Affinity purified
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Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
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Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
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UniProt Number:
Q70E73
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Entrez Gene Number:
NP_998754
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Gene Symbol:
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RAPH1
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ALS2CR18
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ALS2CR9
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KIAA1681
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LPD
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PREL2
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RMO1
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Alternate Names:
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Ras-associated and pleckstrin homology domains-containing protein 1
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RAPH1
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Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein
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Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein
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Lamellipodin
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Proline-rich EVH1 ligand 2
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PREL-2
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Protein RMO1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
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Western Blotting
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Immunocytochemistry
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Product Name:
Anti-Lamellipodin
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Concentration:
1 mg/mL
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Antibody Type:
Polyclonal Antibody
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Qty/Pk:
100 μg
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Format:
Affinity Purified
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Host:
Rabbit
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