货号：ABT147

品牌：Merck Millipore

规格：100Ug

目录价：￥4497.00

市场价格：￥3822.45

会员价格：￥3597.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Claudin-1 Antibody | ABT147 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the cytoplasmic domain of Claudin-1. View All» Molecular Weight: ~18 kDa observed. The calculated molecular weight is 23 kDa, however Claudin-1 has been shown as a ~18 kDa band in western blots (Sjo¨, A., et al. (2010). J Membrane Biol. 236:181-189). View All» Epitope: Cytoplasmic domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Claudin-1. View All» Background Information: Claudin-1 (Senescence-associated epithelial membrane protein) is an integral membrane protein. It interacts with Claudin-2, and possibly occludin, to form tight junctions in epithelial and endothelial cells. Tight junctions are intercellular structures, which function as barriers between cells. They play an important role in regulating paracellular transport, and preventing the diffusion and mixing of apical and basolateral lipids. Previous studies suggest that Claudin-1 may play a role in the migration of neural crest cells during embryonic development. Mutations in Claudin-1 cause ichthyosis-sclerosing cholangitis neonatal syndrome. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Bovine, Rhesus Macaque, and Equine based on 100% sequence homology. Other homologies: Mouse (95 % sequence homology) and Rat (91% sequence homolgy). View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Claudin-1 in 10 µg of A431 cell lysate. View All» Purification Method: Protein A purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O95832 View All» Entrez Gene Number: NP_066924 View All» Gene Symbol:

• CLDN1

• CLD1

• SEMP1
  View All» Alternate Names:
  • Claudin-1

  • Senescence-associated epithelial membrane protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-Claudin-1 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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