货号：ABT154

品牌：Merck Millipore

规格：100Ug

目录价：￥4497.00

市场价格：￥3822.45

会员价格：￥3597.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cerberus Antibody | ABT154 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~38 kDa observed. Cerberus has a calculated molecular weight of 30 kDa; however this protein migrates to ~38 kDa in western blots. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Cerberus. View All» Background Information: The cerberus protein is expressed in the anterior region of the gastrula and is a member of the cysteine superfamily. Studies show cerberus induces differentiation of structural components in the head during embryonic development. Data also shows that a segmental pattern of cerberus is also observed in nascent and newly formed somites suggesting an additional role in development of the axial skeleton, musculature, and peripheral nervous systems. Cerberus is secreted in the surrounding extracellular space and functions by inhibiting signaling molecules. Research indicates the neural-inducing and mesoderm-inhibiting activities of cerberus results from the specific binding of cerberus to BMP and Nodal molecules. Cerberus can bind directly to BMPs and inhibit their activities. View All» Species Reactivity:

• Human

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Bovine based on 100% sequence homology. Other homologies: Mouse and Rat (77% sequence homology). View All» Control: Saos-2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in Saos-2 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Cerberus in 10 µg of Saos-2 cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O95813 View All» Entrez Gene Number: NP_005445 View All» Gene Symbol:
  • CER1

  • DAND4
    View All» Alternate Names:
    • Cerberus

    • Cerberus-related protein

    • DAN domain family member 4
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).SUBUNIT STRUCTURE: Forms monomers and predominantly dimers (By similarity).SUBCELLULAR LOCATION: Secreted Probable. PTM: N-glycosylated (By similarity).SEQUENCE SIMILARITIES: Belongs to the DAN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.SEQUENCE CAUTION: The sequence AAH69503.1 differs from that shown. Reason: Erroneous termination at position 266. Translated as Ser. View All» Product Name: Anti-Cerberus View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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