货号：ABT23

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Enthoprotin Antibody | ABT23 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes Enthoprotin. View All» Molecular Weight: ~ 68 kDa View All» Epitope: Unknown View All» Immunogen: KLH-conjugated linear peptide corresponding to human Enthoprotin. View All» Isotype: IgG View All» Background Information: One of the main pathways by which membrane components and proteins are taken into a cell is through clathrin-mediated endocytosis. This pathway leads to the building and formation of clathrin-coated pits, also known as CCVs. Enthoprotin is a highly enriched protein localized on the CCVs, interacting with AP1 and Arf-binding protein 2, both clathrin adaptors. Through the binding of the clathrin heavy chain by its COOH-terminal domain, Enthoprotin induces clathrin production. Abnormalities in the gene encoding for Enthoprotin affect genetic susceptibility to Schizophrenia type I, a highly heritable psychosis. Enthoprotin is expressed throughout tissue types at intermediate to low levels. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Western Blot Analysis: 1:1,000 dilution from a previous lot detected Enthoprotin in 10 µg of C2C12, L6, NIH/3T3, and RAW264.7 cell lysates. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected Enthoprotin in 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q14677 View All» Entrez Gene Number: NP_055481 View All» Gene Symbol:
  • EPNR

  • ENTH

  • EPN4

  • CLINT

  • Clint

  • EPSINR
    View All» Alternate Names:
    • clathrin interactor 1

    • clathrin interacting protein localized in the trans-Golgi region

    • enthoprotin

    • EpsinR

    • Epsin-4

    • Enthoprotin

    • Epsin-related protein

    • Clathrin-interacting protein localized in the trans-Golgi region

    • epsin 4
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. SUBUNIT STRUCTURE: Binds clathrin heavy chain, GGA2, AP-2 and AP1G1.SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle › clathrin-coated vesicle. Note: Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network. TISSUE SPECIFICITY: Ubiquitously expressed at low to intermediate levels. INVOLVEMENT IN DISEASE: Defects in CLINT1 contributes to genetic susceptibility to schizophrenia type 1 locus (SCZD1) [MIM:181510]. Schizophrenia [MIM:181500] is a psychosis, a disorder of thought and sense of self. Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. No objective biological test for schizophrenia exists. Schizophrenia is a common disorder with a lifetime prevalence of approximately 1%. It is highly heritable but the genetics are complex. SEQUENCE SIMILARITIES: Belongs to the epsin family.Contains 1 ENTH (epsin N-terminal homology) domain. View All» Product Name: Anti-Enthoprotin View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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