货号：ABT34

品牌：Merck Millipore

规格：100Ug

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Podoplanin Antibody | ABT34 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Podoplanin at the extracellular domain. View All» Molecular Weight: ~27 kDa observed. Uniprot describes 4 isoforms produced by alternative splicing with molecular weights of ~17, ~18, and two at ~25 kDa. The calculated molecular weight of this protein is 25 kDa, but can be observed at ~27 kDa due to high glycosylation. View All» Epitope: Extracellular domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human Podoplanin at the extracellular domain. View All» Background Information: Podoplanin, also known as T1 alpha and Aggrus, is a mucin-type transmembrane glycoprotein with extensive O-glycosylation. It is specifically expressed by lymphatic endothelial cells but not blood vascular endothelial cells. Podoplanin regulates lymphatic vascular formation and platelet aggregation and is thought to be involved in cell migration and/or actin cytoskeleton organization. Podoplanin expression in keratinocytes induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility, and decreased cell adhesion. Podoplanin does not have any effect on folic acid or amino acid transport nor does it function as a water channel or as a regulator of aquaporin-type water channels. View All» Species Reactivity:

• Human

• Mouse

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. Predicted to react with Chimpanzee based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Podoplanin in colorectal carcinoma tissue. View All» Control: Human lung tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human lung tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Podoplanin on 10 µg of human lung tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q86YL7 View All» Entrez Gene Number: NP_006465 View All» Gene Symbol:
  • PDPN

  • GP36
    View All» Alternate Names:
    • Podoplanin

    • Aggrus

    • Glycoprotein 36

    • Gp36

    • PA2.26 antigen

    • T1-alpha

    • T1A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). Cell projection › filopodium membrane; Single-pass type I membrane protein (By similarity). Cell projection › lamellipodium membrane; Single-pass type I membrane protein (By similarity). Cell projection › microvillus membrane; Single-pass type I membrane protein (By similarity). Cell projection › ruffle membrane; Single-pass type I membrane protein (By similarity). Note: Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles (By similarity). TISSUE SPECIFICITY: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas. PTM: Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. The N-terminus is blocked (By similarity). SEQUENCE SIMILARITIES: Belongs to the podoplanin family.SEQUENCE CAUTION: The sequence AAM73655.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAO22143.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAC11550.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAC11557.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAG35495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. View All» Product Name: Anti-Podoplanin View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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