货号：ABT47

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Claudin-7 Antibody | ABT47 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~22 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human Claudin-7. View All» Background Information: Claudin-7 is a member of a family of claudins that are tight junction integral membrane proteins with four transmembrane domains and two extracellular loops. Claudin-7 has been shown to be under-expressed in invasive ductal carcinomas and colorectal carcinomas as compared to normal epithelial cells. Claudin-7 differs from other claudins because it has both structural and regulatory functions, regulating the expression of prostate specific antigen. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Control: BALB3T3/A31 cell lysate View All» Quality Assurance: Evaluated by Western Blot in BALB3T3/A31 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Claudin-7 in 10 µg of BALB3T3/A31 cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O95471 View All» Entrez Gene Number: NP_001171951 View All» Gene Symbol:
  • CLDN7

  • CEPTRL2

  • CPETRL2
    View All» Alternate Names:
    • Claudin-7

    • CLDN-7
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found. View All» UniProt Summary: FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity).SUBUNIT STRUCTURE: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM. Ref.10SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction › tight junction. Note: Co-localizes with EPCAM at the lateral cell membrane and tight junction. TISSUE SPECIFICTY: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. INDUCTION: By androgens. PTM: Phosphorylated.SEQUENCE SIMILARITIES: Belongs to the claudin family.SEQUENCE CAUTION: The sequence AAP97219.1 differs from that shown. Reason: Frameshift at positions 18 and 23. View All» Product Name: Anti-Claudin-7 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-159783.htm
      © Merck Millipore代理ABT47 Anti-Claudin-7 Antibody;store at +2℃ to +8℃，产品报价联系微信jinshanbio