金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: B-Raf Long Name: v-Raf Murine Sarcoma Viral Oncogene Homolog B1 Aliases: BRAF1; RAFB1 Entrez Gene IDs: 673 (Human); 114486 (Rat) Background: B-Raf The Raf serine/threonine kinases are effectors of Ras that function as MAP3Ks in the ERK phosphorylation cascade. Mammals express three Raf proteins: Raf-1 (C-Raf); A-Raf; and B-Raf, strongly expressed in fetal brain and adult cerebrum. Mice with a targeted disruption of the B-raf gene die of vascular defects during mid-gestation. B-raf mutations have been found in two-thirds of malignant melanomas, with the single substitution V599E in the kinase domain the most frequent occurrence.