货号：ABT60

品牌：Merck Millipore

规格：

目录价：￥3943.00

市场价格：￥3351.55

会员价格：￥3154.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Whamm Antibody | ABT60 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 90 kDa calculated View All» Immunogen: KLH-conjugated linear peptide corresponding to human Whamm. View All» Background Information: Whamm (WASP homolog associated with actin, membranes, and microtubules) is a mammalian nucleation-promoting factor that controls many cellular components through the Arp2/3 complex. Whamm seems also to be an essential regulator of membrane dynamics at the intersection of the actin and microtubule cytoskeletons. Whamm organizes the cytoskeleton and has a part to play in the structure and effectiveness of the Golgi complex. Whamm and other similar members of the Wiskott-Aldrich Syndrome family of proteins share an actin/Arp2/3-interactin WCA site that has not been seen in this type of protein before. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution of a previous lot of this antibody detected Whamm in NIH/3T3 cells. This antibody positively stains cytoplasm and membrane. The staining pattern is as expected: stains the membrane/cytoplasm, including ER, Golgi, etc,. Staining is also localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Staining is also detected in tubulo-vesicular structures in the cell periphery that frequently localized along microtubules. View All» Control: Fibromuscular stroma of human prostate and distal and proximal convoluted tubules in human kidney tissues. View All» Quality Assurance: Evaluated by Immunohistochemistry in fibromuscular stroma of human prostate or distal and proximal convoluted tubules in human kidney tissues.Immunohistochemistry (paraffin) Analysis: A 1:500 dilution of this antibody detected Whamm in fibromuscular stroma of human prostate or distal and proximal convoluted tubules in human kidney tissues. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8TF30 View All» Entrez Gene Number: AB075851 or AK097947 View All» Gene Symbol:
  • WHAMM

  • KIAA1971

  • WHDC1
    View All» Alternate Names:
    • WASP homolog-associated protein with actin, membranes and microtubules

    • WAS protein homology region 2 domain-containing protein 1

    • WH2 domain-containing protein 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex (by similarity).SUBUNIT STRUCTURE: Interacts with actin, ACTR3 and microtubules.SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane. Golgi apparatus › cis-Golgi network. Note: Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules.TISSUE SPECIFICITY: Expressed in brain, lung, heart, colon and kidney (at protein level).DOMAIN: The N-terminal region associates with membranes, the coiled-coil region binds to microtubules and the WH2 domains promotes actin nucleation. SEQUENCE SIMILARITIES: Contains 2 WH2 domains.SEQUENCE CAUTION: The sequence BAB85557.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC05201.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Whamm View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-159796.htm
        © Merck Millipore代理ABT60 Anti-Whamm (rabbit polyclonal)，产品报价联系微信jinshanbio