货号：ABT64

品牌：Merck Millipore

规格：

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Inscuteable Antibody | ABT64 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~63 kDa observed. Uncharacterized bands may be observed at ~70-85 kDa and ~225 kDA in some cell lysates. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to the human protein inscuteable homolog. View All» Background Information: Inscuteable (minsc or protein inscuteable homolog) is known to act as key regulator of spindle orientation in Drosophila. During mammalian neurogenesis, it is expressed temporally and spatially and is thought to influence the orientation of neural progenitor divisions, which are important for cell differentiation in the retina. Aside from its ability to influence the cytoskeletal structure of neural progenitor cells, it is suggested that Gi-alpha and inscuteable may play a role in regulating cellular stress associated with protein-processing pathologies. In particular, inscuteable augments the distribution of AGS3 within the aggresome whereas the AGS3 binding partner, Gi-alpha, is shown to rescue it from the aggresome. View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Immunohistochemistry Analysis: 2 µg/mL from a representative lot detected Inscuteable in paraffin-embedded human kidney and colon tissues.Western Blot Analysis: A previous lot of this antibody was used to detect Inscuteable in L6 cell lysates. View All» Control: Human liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human liver tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Inscuteable in human liver tissue lysate. View All» Purification Method: Protein A Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q1MX18 View All» Entrez Gene Number: NP_001027024 View All» Gene Symbol: INSC View All» Alternate Names: Protein inscuteable homolog View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki, T., et al. (2006). Biocehm BioPhyis Res Commun. 341(4):1001-1006.). View All» UniProt Summary: FUNCTION: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium.SUBUNIT STURCTURE: Interacts with ALS2CR19/PAR3-beta, F2RL2/PAR3, GPSM1/AGS3 and GPSM2/LGN. Ref.1SUBCELLUALR LOCATION: Cytoplasm. Note: Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells. View All» Product Name: Anti-Inscuteable View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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