货号：ABT66

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CADM1 Antibody | ABT66 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~48 kDa & 37 kDa observed.Isoform 1 (48 kDa), Isoform 2 (37 kDa). View All» Immunogen: Linear peptide corresponding to human CADM1. View All» Background Information: CADM1 (also known as cell adhesion molecule 1, Nectin-like protein 2, synaptic cell adhesion molecule. IgSF4 and TSLC-1) is a tumor suppressor part of the immunoglobulin superfamily and has been found to show reduced expression in many different solid tumors. CADM1 has also been found to play a role in the formation of epithelia-like cell structure. Recent research has also linked CADM1 to mediating emotional and social behaviors and motor skills. CADM1 may also be important in psychiatric and behavioral disorders such as autism. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected CADM1 in NIH/3T3, A431, and HeLa cells. View All» Control: PC3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC3 cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected CADM1 in 10 µg of PC3 cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9BY67 View All» Entrez Gene Number: NP_001091987 View All» Gene Symbol:
  • CADM1

  • IGSF4

  • IGSF4A

  • NECL2

  • SYNCAM

  • TSLC1
    View All» Alternate Names:
    • Cell adhesion molecule 1

    • Immunoglobulin superfamily member 4

    • IgSF4

    • Nectin-like protein 2

    • NECL-2

    • Spermatogenic immunoglobulin superfamily

    • SgIgSF

    • Synaptic cell adhesion molecule

    • SynCAM

    • Tumor suppressor in lung cancer 1

    • TSLC-1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. SUBUNICT STRUCTURE: Homodimer. Interacts with CRTAM and EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note: Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder. Ref.4 UniProtKB Q8R5M8DOMAIN: The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC. Ref.7 Ref.11SEQUENCE SIMILARITIES: Belongs to the nectin family.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Product Name: Anti-CADM1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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