货号：ABT96

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Inversin Antibody | ABT96 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~165/12 kDa observed. Uniprot describes 3 isoforms at ~11, ~100, and ~118 kDa. The calculated molecular weights are 11 and 118 kDa, however Inversin has been shown as a ~12 and ~165 kDa band in western blots (Nurnberger, J., et al. (2004). J Am Soc Nephrol. 15:1700–1710.). Uncharacterized bands may appear at ~45, ~53, and ~55 kDa. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Inversin. View All» Background Information: Inversin is a tubulin-associated protein, which is highly expressed in the cilia of renal tubules. It contains sixteen ankyrin repeats at the N-terminus and two IQ domains at the C-terminus. The ankyrin repeats facilitate protein-protein interactions, whereas the IQ domains are involved in calmodulin binding. Previous studies have indicated that inversin modulates the Wnt signaling pathway, and interacts with a plethora of intracellular signaling targets, including Disheveled, Frizzled-8, alpha- and beta catenins, NPHP1, and NPHP3. Inversin is localized to mitotic spindle fibers, and plays an important role in renal development and left-right axis determination. Defects in inversin result in nephronophthisis type 2, an autosomal recessive cystic kidney disease. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rhesus Macaque based on 100% sequence homology. No homology to Rat was found. View All» Application Notes: Western Blot Analysis: 1 µg/mL from a representative lot detected Inversin in 10 µg of human liver tissue lysate.Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Inversin in human kidney tissue. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Inversin in 10 µg of HEK293 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y283 View All» Entrez Gene Number: NP_055240 View All» Gene Symbol:

• INVS

• INV

• NPHP2
  View All» Alternate Names:
  • Inversin

  • Inversion of embryo turning homolog

  • Nephrocystin-2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Product Name: Anti-Inversin View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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