货号:ABT99
品牌:Merck Millipore
规格:EA
目录价:¥3588.00
市场价格:¥3049.80
会员价格:¥2870.40
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Description:
Anti-Myosin-14 Antibody | ABT99
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Promotional Text:
Special Shipping Offer on Antibodies100% Performance Guaranteed
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Specificity:
This antibody recognizes the coiled-coil domain of Myosin-14.
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Molecular Weight:
~230 kDa observed
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Epitope:
Coiled-coil domain
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Immunogen:
KLH-conjugated linear peptide corresponding to the coiled-coil domain of human Myosin-14.
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Background Information:
As a member of the nonmuscle/smooth muscle myosin II family, Myosin-14 serves as a protein motor that binds to filamentous actin in an ATP-dependent manner. Nonmuscle myosins, such as Myosin-14, form filaments at relatively low ionic strength and share certain biological properties with cardiac, skeletal, and smooth muscle myosin. Myosin-14 is expressed in both muscle and nonmuscle cells, and is abundant in certain organs. Myosin-14 plays a role in cell shape, cytokinesis, and contributes to specialized cellular functions such as capping and secretion. Mutations in the gene MYH14 are associated with peripheral neuropathy, myopathy, hoarseness, and hearing loss.
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Species Reactivity:
Human
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Species Reactivity Note:
Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology.
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Application Notes:
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Myosin-14 in human colorectal and normal human colon tissues.
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Control:
Human lung tissue lysate
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Quality Assurance:
Evaluated by Western Blot in human lung tissue lysate.Western Blot Analysis: 0.2 µg/mL of this antibody detected Myosin-14 in 10 µg of human lung tissue lysate.
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Purification Method:
Affinity purified
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Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
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Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
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UniProt Number:
Q7Z406
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Entrez Gene Number:
NP_079005
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Gene Symbol:
MYH14
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Alternate Names:
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Myosin-14
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Myosin heavy chain 14
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Myosin heavy chain, non-muscle IIc
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Non-muscle myosin heavy chain IIc
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NMHC II-C
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
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Western Blotting
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Immunohistochemistry
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Product Name:
Anti-Myosin-14
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Concentration:
1 mg/mL
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Antibody Type:
Polyclonal Antibody
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Qty/Pk:
100 μg
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Format:
Affinity Purified
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Host:
Rabbit
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