金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: FKBP38 Long Name: 38 kDa FK506 Binding Protein Aliases: FKBP8 Entrez Gene IDs: 23770 (Human); 14232 (Mouse); 290652 (Rat) Background: FKBP38

FKBP38, also known as FKBP8, is a 355 amino acid (aa) protein with a calculated molecular weight of 38.7 kDa and an apparent molecular mass of ~60 - 64 kDa in SDS-PAGE. FKBP38 binds to and inhibits calcineurin even in the absence of FK506, indicating that FKBP38 is a constitutively active inhibitor of calcineurin. Additionally, FKBP38 immunoprecipitates with Bcl-2 and Bcl-xL, suggesting that FKBP38 may regulate apoptosis by anchoring Bcl-2 and Bcl-xL to mitochondrial membranes. Mouse FKBP38 shares 94% and 87% sequence identity with human and rat FKBP38, respectively.