货号：AG565

品牌：Merck Millipore

规格：EA

目录价：￥2150.00

市场价格：￥1827.50

会员价格：￥1720.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Polycystin-2 Control Peptide for AB9088 View All» Trade Name: Chemicon (Millipore) View All» Qty/Pk: 100 μg View All» Key Applications: Cell Function Assay View All» Application Notes: Antibody blocking (AB9088)Optimal working concentration must be determined by the end user. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease. View All» UniProt Summary: FUNCTION: SwissProt: Q13563 # Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.SIZE: 968 amino acids; 109691 Da SUBUNIT: Interacts with PKD1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).TISSUE SPECIFICITY: Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.DOMAIN:SwissProt: Q13563 The C-terminal is implicated in the interaction with PKD1.DISEASE: SwissProt: Q13563 # Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy.SIMILARITY: Belongs to the polycystin family. & Contains 1 EF-hand domain. View All» Brand Family: Chemicon View All» Presentation: Liquid in sterile distilled water. View All» Format: Purified View All» UniProt Number: Q13563 View All» Storage Conditions: Store at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Gene Symbol:

• PKD2

• PKD4

• Polycystwin

• Polycystin-2

• PC2

• polycystwin

• APKD2

• R48321

• MGC138468

• MGC138466
  View All» Product Name: Polycystin-2 Control Peptide for AB9088 View All» Entrez Gene Number: NM_000297.2 View All» Concentration: 2 mg/mL View All»
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