货号：AG657

品牌：Merck Millipore

规格：50Ug

目录价：￥4767.00

市场价格：￥4051.95

会员价格：￥3813.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: DARPP-32, recombinant, His-tagged View All» Trade Name: Chemicon (Millipore) View All» Qty/Pk: 50 µg View All» Key Applications: Western Blotting View All» Application Notes: Phosphatase assays View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q9UD71 # Inhibitor of protein-phosphatase 1.SIZE: 204 amino acids; 22963 Da SUBCELLULAR LOCATION: Cytoplasm.PTM: Dopamine- and cyclic AMP-regulated neuronal phosphoprotein. & Phosphorylation of Thr-34 is required for activity (By similarity).SIMILARITY: SwissProt: Q9UD71 ## Belongs to the protein phosphatase inhibitor 1 family. View All» Species: Human View All» Brand Family: Chemicon View All» Source: Recombinant human DARPP-32, expressed in bacteria with a His-Tag linker. View All» Presentation: 0.5 mg/mL in Tris-buffered saline containing 40% glycerol. View All» Storage Conditions: Store at -20°C for up to 1 year. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Gene Symbol:

• PPP1R1B

• DARPP-32

• FLJ20940

• DARPP32
  View All» Product Name: DARPP-32, recombinant, His-tagged View All» UniProt Number: Q9UD71 View All» Entrez Gene Number:
  • NM_032192.2

  • NM_181505.2
    View All» Purity: >90% by SDS-PAGE View All»
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